The Upjohn Pill and Granule Company sold so many quinine pills in the early years of the twentieth century they became known as the quinine company. Quinine is used to treat malaria and was a very important drug when Europeans and Americans were romping through the jungles of the world. Even in the US, malaria was a big problem for the early settlers until millions of acres of swamps and marshes were drained, thus reducing the breeding grounds for mosquitos. Quinine is no longer the first choice for treatment of malaria due to side-effects but for resistant cases it is still used.